Gastroparesis symptoms and its treatment using low-viscosity soluble dietary fibres

To compare the blood glucose regulation / control ability of 'low-viscosity' test fibres Partially-hydrolysed guar gum (PHGG) and Gum Arabic to the negative control (Water) and positive control (Psyllium Husk). The blood glucose control of the interventions was assessed using pin-prick blood glucose values in response to the interventions, Actilax and the glucose challenge (50 g in 300 mL).;; To compare the symptom severity / tolerability of 'low-viscosity' test fibres Partially-hydrolysed guar gum (PHGG) and Gum Arabic to the negative control (Water) and positive control (Psyllium Husk). The tolerability of the interventions was assessed using the patient-rated American Neurogastroenterology and Motility Society - Gastroparesis Cardinal Symptom Index - Daily Diary (ANMS-GCSI-DD) in response to the interventions, Actilax and the glucose challenge (50 g in 300 mL).

The principal aim of this clinical study was to determine the short-term blood-glucose control and tolerability of Partially-hydrolysed guar gum (PHGG) and Gum Arabic in mild-to-moderate symptom gastroparesis patients. There were four interventions in total, the test fibres PHGG and Gum Arabic, the positive control Psyllium Husk and the negative control Water. The study hypothesizes that the 'low-viscosity' test fibres PHGG and Gum Arabic provide blood glucose regulation / control comparable to the positive control, Psyllium Husk, while causing fewer severe symptoms comparable to the negative control, Water.