NCT03028038

Using Platelet Rich Plasma in Reducing Alveolar Bone Resorption During Rapid Maxillary Expansion

Name: Clinical Trial NCT03028038
Creator: Damascus University
Keywords: Bone Resorption, Platelet Rich Plasma, Phase 1, drug, clinical trial, Syrian

Evaluation of Efficacy of Injectable Platelet-Rich Plasma (PRP) in Reducing Alveolar Bone Resorption Following Rapid Maxillary Expansion (RME): A Cone Beam Computed Tomography (CBCT) Assessment

Damascus University·Phase 1·ClinicalTrials.gov·drugCompleted

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Study focus

Disease/Condition: Bone Resorption
Drug/Device/Intervention: Platelet Rich Plasma
Study type: Interventional
Intervention type: drug

Sponsor & location

Primary sponsor: Damascus University
Location: Damascus, Syrian

Timeline & enrollment

Phase: Phase 1
Start date: Jul 01, 2016
End date: Jul 15, 2018
Enrollment: 16 participants

Primary outcome

Changes in buccal alveolar bone height loss and thickness reduction amount

Summary

The purpose of this study is to determine if the injection of Platelet-rich plasma (PRP) is effective in reducing alveolar bone loss that happens after each rapid maxillary expansion (RME) on the buccal aspect of the posterior teeth.  16 patients with a skeletal maxillary constriction aged between 10-16 years old will get into orthodontic treatment to widen the maxilla using Hyrax appliance.  An amount of patient blood will be withdrawn and centrifuged to get PRP. Then the PRP will be injected in one half of each patient mouth in a split-mouth design, beneath the buccal periosteal of the first molars and first premolars, the halves will be chosen randomly.  High resolution CBCT images will be taken before and after orthodontic treatment to analyze buccal bone thickness and height changes.

ICD-10 classifications

OsteolysisPathological resorption of teethBone donorPostsurgical malabsorption osteoporosisPostsurgical malabsorption osteoporosis with pathological fracture

Data source

Registry: ClinicalTrials.gov
Trial ID: NCT03028038
Type: Non-Device Trial

About this record

Access comprehensive clinical trial information for NCT03028038 through Pure Global AI's free database. This Phase 1 trial is sponsored by Damascus University and is currently Completed. The study focuses on Bone Resorption. Target enrollment is 16 participants.

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