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NCT03806829

The Acute Effects of Commercially Available Drinks on the Endothelial Function of Humans Following a High-fat Meal

Pilot Study: The Acute Effects of Commercially Available Drinks on the Endothelial Function of Humans Following a High-fat Meal
University of the Highlands and Islands·ClinicalTrials.gov·otherCompleted
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Study focus
Disease/Condition
Endothelial Dysfunction
Drug/Device/Intervention
Water
Study type
Interventional
Intervention type
other
Sponsor & location
Primary sponsor
University of the Highlands and Islands
Location
Inverness, United Kingdom
Timeline & enrollment
Phase
N/A
Start date
Jun 06, 2018
End date
Jul 31, 2018
Enrollment
7 participants
Primary outcome

Endothelial (dys)function

Summary

High fat diets are associated with impaired endothelial function and increased cardiovascular
 disease risk amongst our population. These negative effects are likely caused by triglyceride
 induced suppression of nitric oxide, which is produced from the endothelium, and/or an
 increase in oxidative stress.
 
 Interestingly, previous studies have found that some beverages that are high in polyphenols
 and antioxidants may suppress the impairment in endothelial function observed following high
 fat meals/diets. Typically, these studies have investigated the ingestion of red wine, orange
 juice or green tea on outcome measures (typically flow mediated dilatation (FMD) of the
 brachial artery). Despite this previous research, no study has compared the effects of
 different beverages on endothelial outcomes following a high-fat meal within the same
 participants.

ICD-10 classifications
Other peripheral vascular diseasesAtherosclerosis of arteries of extremitiesOther specified peripheral vascular diseasesRenovascular hypertensionOther disorders of arteries and arterioles
Data source
Registry
ClinicalTrials.gov
Trial ID
NCT03806829
Type
Non-Device Trial
About this record

Access comprehensive clinical trial information for NCT03806829 through Pure Global AI's free database. This phase not specified trial is sponsored by University of the Highlands and Islands and is currently Completed. The study focuses on Endothelial Dysfunction. Target enrollment is 7 participants.

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