The Relationship Between the Lack of AT-Ⅲ, PC, PS Activity and PICC-related Thrombosis

The incidence of PICC-RVT

PICC related venous thrombosis (PICC-RVT) is one of the common complications of PICC and the
 main cause of unplanned extubation. Effectively identifying the risk of PICC-RVT in patients
 and preventing PICC-RVT are of great clinical significance. There are many studies on the
 risk factors of VTE at home and abroad, and there are also many studies on the risk
 assessment of PICC catheter-related thrombosis, mostly focusing on sociodemographic data,
 comorbidities, and intubation related factors, while the research on laboratory related
 indicators is limited It involves D-dimer, white blood cell count (WBC), platelet count
 (PLT), etc., but its specificity or positive predictive value is not high, and there is no
 reliable biomarker report. Studies have shown that the decrease or lack of AT-Ⅲ, PC, PS
 activity is one of the mechanisms of hypercoagulable state in patients with cancer, and may
 be a biomarker of thrombosis. Many retrospective studies have also shown that the activities
 of AT-Ⅲ, PC, and PS are related to the occurrence and recurrence of VTE and DVT. The
 pathogenesis is mainly anticoagulant protein defect or decreased expression. However, when
 PICC is implanted in patients with AT-Ⅲ, PC and PS activity defects, whether PICC indwelling
 will become a predisposing factor of thrombosis is not yet known. Therefore, the purpose of
 this study is to understand the rate of anticoagulant protein deficiency in patients with
 tumor PICC-RVT, and to prospectively explore the correlation between the lack of AT-Ⅲ, PC,
 and PS activities and PICC-RVT, and to provide targeted preventive interventions for PICC-RVT
 patients Scientific basis.