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NCT04720573

Reversal of Neuromuscular Blockade and Perioperative Arrhythmias

Influence of the Neuromuscular Blockade and Its Reversal on Perioperative Arrhythmias
Basaksehir Cam & Sakura Şehir Hospital·ClinicalTrials.gov·drugCompleted
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Study focus
Disease/Condition
Neuromuscular Blockade
Drug/Device/Intervention
Neostigmine
Study type
Interventional
Intervention type
drug
Sponsor & location
Primary sponsor
Basaksehir Cam & Sakura Şehir Hospital
Location
Istanbul, Turkey
Timeline & enrollment
Phase
N/A
Start date
Jun 01, 2019
End date
Nov 01, 2019
Enrollment
80 participants
Primary outcome

Significant arrhythmic event

Summary

Patients scheduled for elective abdominopelvic laparoscopic surgery under general anesthesia
 were included. Rocuronium was used for the neuromuscular blockade (NMB) and the level of NMB
 was monitored with train-of-four (TOF) measurements. The participants from whom informed
 consent had been received were allocated to two groups according to the agent used for
 reversal of NMB, sugammadex, or neostigmine. The ECG recordings of the subjects were followed
 with a rhythm Holter device throughout the procedure until the postoperative 12th hour.
 Additionally, preoperative and immediate postoperative 12-lead ECGs were evaluated for
 corrected QT calculations and QT dispersion. Proarrhythmogenicity was assessed with QT
 related measurements. The documented arrhythmic events on the Holter monitoring were
 designated as clinical end-points.

ICD-10 classifications
Skeletal muscle relaxants [neuromuscular blocking agents]Poisoning: Skeletal muscle relaxants [neuromuscular blocking agents]Other neuromuscular dysfunction of bladderNeuromuscular dysfunction of bladder, unspecifiedNeuromuscular scoliosis
Data source
Registry
ClinicalTrials.gov
Trial ID
NCT04720573
Type
Non-Device Trial
About this record

Access comprehensive clinical trial information for NCT04720573 through Pure Global AI's free database. This phase not specified trial is sponsored by Basaksehir Cam & Sakura Şehir Hospital and is currently Completed. The study focuses on Neuromuscular Blockade. Target enrollment is 80 participants.

This page provides complete trial specifications, intervention details, outcomes, and location information. Pure Global AI offers free access to ClinicalTrials.gov data, helping medical device and pharmaceutical companies navigate clinical research efficiently.