Endoscopic Third Ventriculostomy for Adults: A Prognostic Model for Success

ETV success

Endoscopic Third Ventriculostomy for Adults with Hydrocephalus: Creating a Prognostic Model
 for Success - A Retrospective Multicenter Study
 
 Background: Endoscopic third ventriculostomy (ETV) is becoming an increasingly widespread
 treatment for hydrocephalus, but most of the research is based on paediatric populations. The
 ETV Success Score (ETVSS) was developed in 2009 to predict the outcome of ETV in children.
 There is no similar tool for predicting outcome in adults.
 
 Objective: The purpose of this study is to create a prognostic model to predict the success
 of ETV for adult patients with hydrocephalus
 
 Methods: The study will adhere to the TRIPOD reporting guidelines and will be conducted as a
 retrospective chart review of all patients ≥18 years old treated with ETV at the
 participating centres between Jan 1st, 2010 and Dec 31st, 2018. Data collection is conducted
 locally in REDCap. Univariate analyses will be used to identify several strong predictors to
 be included in a multivariate logistic regression model. The model will be validated using
 K-fold cross validation. Discrimination will be assesses using AUROC and calibration with
 calibration belt plots.
 
 Expected outcomes: The ability to predict who will benefit from an ETV will allow better
 primary patient selection both for ETV and shunting. This would reduce additional second
 procedures due to primary treatment failure. A success score specific for adults could also
 be used as a communication tool to provide better information and guidance to patients.