Comparison of the Effects of Sevoflurane and Desflurane on Endothelial Glycocalyx - Trial NCT05068336
Access comprehensive clinical trial information for NCT05068336 through Pure Global AI's free database. This phase not specified trial is sponsored by Kocaeli Derince Education and Research Hospital and is currently Completed. The study focuses on Endothelial Dysfunction. Target enrollment is 50 participants.
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Study Focus
Sponsor & Location
Kocaeli Derince Education and Research Hospital
Timeline & Enrollment
N/A
Aug 25, 2021
Nov 04, 2021
Primary Outcome
glycocalyx components
Summary
The glycocalyx is a dynamic and complex biochemical structure composed of proteoglycans,
 glycoproteins, and soluble proteins. The glycocalyx interacts with various proteins such as
 albumin and orosomucoid to form a thick surface layer on the vessel surface that is
 physiologically active. This is called the endothelial surface layer. This structure is
 constantly changing with the blood flowing in the vein. The glycocalyx regulates oncotic
 pressure and also prevents leukocyte and platelet adhesion to the endothelium. Endothelial
 cell dysfunction is a valuable marker of increased vascular permeability and impaired
 angiogenesis due to cardiovascular, thoracic, renal, and metabolic diseases.
ICD-10 Classifications
Data Source
ClinicalTrials.gov
NCT05068336
Non-Device Trial