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NCT05068336

Comparison of the Effects of Sevoflurane and Desflurane on Endothelial Glycocalyx

Comparison of the Effects of Sevoflurane and Desflurane on Endothelial Glycocalyx in Laparoscopic Hysterectomy Surgery
Kocaeli Derince Education and Research Hospital·ClinicalTrials.gov·diagnostic testCompleted
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Study focus
Disease/Condition
Endothelial Dysfunction
Drug/Device/Intervention
desflurane anesthesia
Study type
Observational
Intervention type
diagnostic test
Sponsor & location
Primary sponsor
Kocaeli Derince Education and Research Hospital
Location
İstanbul, Turkey
Timeline & enrollment
Phase
N/A
Start date
Aug 25, 2021
End date
Nov 04, 2021
Enrollment
50 participants
Primary outcome

glycocalyx components

Summary

The glycocalyx is a dynamic and complex biochemical structure composed of proteoglycans,
 glycoproteins, and soluble proteins. The glycocalyx interacts with various proteins such as
 albumin and orosomucoid to form a thick surface layer on the vessel surface that is
 physiologically active. This is called the endothelial surface layer. This structure is
 constantly changing with the blood flowing in the vein. The glycocalyx regulates oncotic
 pressure and also prevents leukocyte and platelet adhesion to the endothelium. Endothelial
 cell dysfunction is a valuable marker of increased vascular permeability and impaired
 angiogenesis due to cardiovascular, thoracic, renal, and metabolic diseases.

ICD-10 classifications
Other peripheral vascular diseasesAtherosclerosis of arteries of extremitiesOther specified peripheral vascular diseasesRenovascular hypertensionOther disorders of arteries and arterioles
Data source
Registry
ClinicalTrials.gov
Trial ID
NCT05068336
Type
Non-Device Trial
About this record

Access comprehensive clinical trial information for NCT05068336 through Pure Global AI's free database. This phase not specified trial is sponsored by Kocaeli Derince Education and Research Hospital and is currently Completed. The study focuses on Endothelial Dysfunction. Target enrollment is 50 participants.

This page provides complete trial specifications, intervention details, outcomes, and location information. Pure Global AI offers free access to ClinicalTrials.gov data, helping medical device and pharmaceutical companies navigate clinical research efficiently.