Impact of Muscle Temperature on Muscle Growth and Breakdown: Cooling During Resistance Training - Trial NCT05302791
Access comprehensive clinical trial information for NCT05302791 through Pure Global AI's free database. This phase not specified trial is sponsored by University of Nebraska and is currently Completed. The study focuses on Exercise Training. Target enrollment is 12 participants.
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Study Focus
Sponsor & Location
University of Nebraska
Timeline & Enrollment
N/A
May 01, 2022
Oct 01, 2022
Primary Outcome
Western Blot for mammalian target of rapamycin signaling,Western Blot for mammalian target of rapamycin signaling,Western Blot for Ribosomal protein S6 kinase beta-1 signaling,Western Blot for Ribosomal protein S6 kinase beta-1 signaling,Western Blot for Eukaryotic translation initiation factor 4E-binding protein 1 signaling,Western Blot for Eukaryotic translation initiation factor 4E-binding protein 1 signaling,RT-qPCR for F-Box Protein 32 (FBXO32),RT-qPCR for Forkhead Box O3 (FOXO3a),RT-qPCR for Tripartite Motif Containing 63 (TRIM63),RT-qPCR for Growth/Differentiation Factor 8 (MSTN),RT-qPCR for Myogenic Factor 5 (MYF5),RT-qPCR for Myogenic Factor 6 (MYF6),RT-qPCR for Myocyte Enhancer Factor 2A (MEF2a),RT-qPCR for Myogenic Differentiation 1 (MYOD1),RT-qPCR for Myogenin (MYOG),RT-qPCR for Ribosomal Protein S3 (RPS3),RT-qPCR for Ribosomal Protein L3 Like (RPL3L)
Summary
The purpose of this study is to examine the effect of human skeletal muscle temperature
 during resistance exercise on myogenic and proteolytic signaling. Subjects will perform
 bilateral resistance exercise bouts at an intensity that should stimulate a muscle growth
 response in the Vastus Lateralis. During the resistance exercise, the subjects will receive a
 cold (10°C) intervention on the experimental limb, while receiving a neutral temperature
 intervention (22°C) on the control limb.
ICD-10 Classifications
Data Source
ClinicalTrials.gov
NCT05302791
Device Trial