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NCT05302791

Impact of Muscle Temperature on Muscle Growth and Breakdown: Cooling During Resistance Training

University of Nebraska·ClinicalTrials.gov·device·Device trialCompleted
View on ClinicalTrials.gov →
Study focus
Disease/Condition
Exercise Training
Drug/Device/Intervention
Muscle Cooling
Study type
Interventional
Intervention type
device
Sponsor & location
Primary sponsor
University of Nebraska
Location
Omaha, United States of America
Timeline & enrollment
Phase
N/A
Start date
May 01, 2022
End date
Oct 01, 2022
Enrollment
12 participants
Primary outcome

Western Blot for mammalian target of rapamycin signaling,Western Blot for mammalian target of rapamycin signaling,Western Blot for Ribosomal protein S6 kinase beta-1 signaling,Western Blot for Ribosomal protein S6 kinase beta-1 signaling,Western Blot for Eukaryotic translation initiation factor 4E-binding protein 1 signaling,Western Blot for Eukaryotic translation initiation factor 4E-binding protein 1 signaling,RT-qPCR for F-Box Protein 32 (FBXO32),RT-qPCR for Forkhead Box O3 (FOXO3a),RT-qPCR for Tripartite Motif Containing 63 (TRIM63),RT-qPCR for Growth/Differentiation Factor 8 (MSTN),RT-qPCR for Myogenic Factor 5 (MYF5),RT-qPCR for Myogenic Factor 6 (MYF6),RT-qPCR for Myocyte Enhancer Factor 2A (MEF2a),RT-qPCR for Myogenic Differentiation 1 (MYOD1),RT-qPCR for Myogenin (MYOG),RT-qPCR for Ribosomal Protein S3 (RPS3),RT-qPCR for Ribosomal Protein L3 Like (RPL3L)

Summary

The purpose of this study is to examine the effect of human skeletal muscle temperature
 during resistance exercise on myogenic and proteolytic signaling. Subjects will perform
 bilateral resistance exercise bouts at an intensity that should stimulate a muscle growth
 response in the Vastus Lateralis. During the resistance exercise, the subjects will receive a
 cold (10°C) intervention on the experimental limb, while receiving a neutral temperature
 intervention (22°C) on the control limb.

ICD-10 classifications
Orthoptic trainingLack of physical exerciseOther physical therapyCardiac rehabilitationExhaustion due to excessive exertion
Data source
Registry
ClinicalTrials.gov
Trial ID
NCT05302791
Type
Device Trial
About this record

Access comprehensive clinical trial information for NCT05302791 through Pure Global AI's free database. This phase not specified trial is sponsored by University of Nebraska and is currently Completed. The study focuses on Exercise Training. Target enrollment is 12 participants.

This page provides complete trial specifications, intervention details, outcomes, and location information. Pure Global AI offers free access to ClinicalTrials.gov data, helping medical device and pharmaceutical companies navigate clinical research efficiently.