Pure Global
NCT05350813

Impact of Procalcitonin-guided Algorithm on Early Discontinuation of Antibiotic Therapy

Impact of Procalcitonin-guided Algorithm on Early Discontinuation of Antibiotic Therapy in Pediatric Intensive Care Units : a Multicenter Randomized Controlled Trial
University Hospital, Toulouse·ClinicalTrials.gov·procedureNot yet recruiting
View on ClinicalTrials.gov →
Study focus
Disease/Condition
Bacterial Infections
Drug/Device/Intervention
Measurement of the PCT plasma levels
Study type
Interventional
Intervention type
procedure
Sponsor & location
Primary sponsor
University Hospital, Toulouse
Location
Amiens,Clermont-Ferrand,Nantes,Toulouse, France
Timeline & enrollment
Phase
N/A
Start date
Jan 01, 2023
End date
Mar 01, 2024
Enrollment
296 participants
Primary outcome

Total duration of antibiotic therapy (in days) for a suspected or proven bacterial infection, including the first episode and recurrences occurring within 28 days following the day of randomization

Summary

In this randomized controlled open-label trial, conducted in 7 French Pediatric and Neonatal
 Intensive Care Units (ICUs), investigator team hypothesize that the use of a procalcitonin
 (PCT)-guided algorithm to discontinue antibiotic treatment will decrease antibiotic duration
 in critically ill children treated for a suspected or proven bacterial infection. Two hundred
 and ninety-six eligible patients will be randomly assigned in two groups: either PCT-guided
 or standard-of-care antibiotic discontinuation, and monitored over 28 days, until the end of
 their hospitalization, or up to the end of antibiotic treatment for bacterial infection
 recurrence occurring up to 28 days after the day of randomization.

ICD-10 classifications
Bacterial infection, unspecifiedBacterial, viral and other infectious agentsOther bacterial intestinal infectionsOther bacterial diseasesOther specified bacterial intestinal infections
Data source
Registry
ClinicalTrials.gov
Trial ID
NCT05350813
Type
Non-Device Trial
About this record

Access comprehensive clinical trial information for NCT05350813 through Pure Global AI's free database. This phase not specified trial is sponsored by University Hospital, Toulouse and is currently Not yet recruiting. The study focuses on Bacterial Infections. Target enrollment is 296 participants.

This page provides complete trial specifications, intervention details, outcomes, and location information. Pure Global AI offers free access to ClinicalTrials.gov data, helping medical device and pharmaceutical companies navigate clinical research efficiently.