Perioperative Plasma Levels of Glycocalyx Markers in Colon Surgery. - Trial NCT05419882

Timeline & Enrollment

Primary Outcome

To analyze plasma levels changes of heparan-sulphate and syndecan-1 in perioperative period of colorectal surgery

Summary

The glycocalyx is a layer of macromolecules that covers the luminal surface of the
 endothelium, playing an important role in vascular homeostasis. Several studies have shown
 that in conditions of sepsis there is a degradation of the glycocalyx mediated by
 inflammatory mechanisms, releasing its components into the bloodstream. These glycocalyx
 fragments can be measured in blood plasma, showing a correlation between these markers and
 organ dysfunction, severity and mortality in sepsis situations. However, despite the great
 interest in glycocalyx biomarkers, their values in patients undergoing colorectal surgery are
 not well known. Therefore, verifying whether plasma levels of glycocalyx damage markers
 increase in the perioperative period of colorectal surgery is of great interest at the
 pathophysiological and clinical level, since the correlation of these markers with
 postoperative clinical evolution is unknown. In this study we want to determine the plasma
 levels of Heparan-sulphate and Syndecan-1, two of the most important constituents of the
 glycocalyx, and perform several measurements to form a time course of the plasma levels of
 these markers, in order to compare the different subgroups of patients undergoing colorectal
 surgery based on their clinical and surgical characteristics.

ICD-10 Classifications