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NCT05474638

Comparison of Mechanomyographic 100 Versus 200 Hz 5 Second Tetanic Fade Ratios During Neuromuscular Block Recovery

Centre Hospitalier Universitaire Dinant Godinne - UCL Namur·ClinicalTrials.gov·device·Device trialNot yet recruiting
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Study focus
Disease/Condition
Neuromuscular Blockade
Drug/Device/Intervention
Isometric Thumb Force (isometric mechanomyography) compared to TOF-Watch SX (acceleromyography)
Study type
Interventional
Intervention type
device
Sponsor & location
Primary sponsor
Centre Hospitalier Universitaire Dinant Godinne - UCL Namur
Location
Yvoir, Belgium
Timeline & enrollment
Phase
N/A
Start date
Aug 01, 2022
End date
Dec 01, 2022
Enrollment
20 participants
Primary outcome

100 vs 200 Hz Tetanic Fade Ratio comparison

Summary

Two recent pilot studies suggested the potential interest of 100 and 200 Hz tetanic
 stimulations to detect with mechanomyography (MMG) very low levels of residual neuromuscular
 blockade (NMB). The Tetanic Fade Ratio (TFR, residual force after 5 seconds / maximal force)
 measured quantitatively by MMG during tetanic stimulation at 100 or 200 Hz could provide
 today a more consistent response than the train-of-four (TOF) ratio provided by
 acceleromyography (AMG) to this search for detection of low levels of residual NMB.
 
 This study was designed to evaluate for the first time in anesthetized patients the evolution
 of NMB spontaneous recovery with 5-second 100 and 200 Hz tetanic stimulations compared to
 TOF, and to test the hypothesis that a 200 Hz TFR would better and longer detect low levels
 of residual paralysis than AMG TOF ratio and 100 Hz TFR.

ICD-10 classifications
Skeletal muscle relaxants [neuromuscular blocking agents]Poisoning: Skeletal muscle relaxants [neuromuscular blocking agents]Other neuromuscular dysfunction of bladderNeuromuscular dysfunction of bladder, unspecifiedNeuromuscular scoliosis
Data source
Registry
ClinicalTrials.gov
Trial ID
NCT05474638
Type
Device Trial
About this record

Access comprehensive clinical trial information for NCT05474638 through Pure Global AI's free database. This phase not specified trial is sponsored by Centre Hospitalier Universitaire Dinant Godinne - UCL Namur and is currently Not yet recruiting. The study focuses on Neuromuscular Blockade. Target enrollment is 20 participants.

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