NCT05586776

Decolonization to Reduce After-Surgery Events of Surgical Site Infection

Name: Clinical Trial NCT05586776
Creator: University of California, Irvine
Keywords: Surgical Site Infection, 4% Chlorhexidine Gluconate, Phase 4, drug, clinical trial, United States of America

University of California, Irvine·Phase 4·ClinicalTrials.gov·drugNot yet recruiting

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Study focus

Disease/Condition: Surgical Site Infection
Drug/Device/Intervention: 4% Chlorhexidine Gluconate
Study type: Interventional
Intervention type: drug

Sponsor & location

Primary sponsor: University of California, Irvine
Location: Orange,Sacramento,San Francisco, United States of America

Timeline & enrollment

Phase: Phase 4
Start date: Jan 01, 2023
End date: Dec 01, 2028
Enrollment: 2700 participants

Primary outcome

Time to First Post-Discharge Surgical Site Infection

Summary

The DECREASE SSI Trial (Decolonization to Reduce After-Surgery Events of Surgical Site Infection) is a two-arm multi-center individual placebo-controlled randomized (2,700 participants randomized 1:1) clinical trial to reduce post-discharge surgical site infection following open colon or small bowel surgery by comparing chlorhexidine bathing plus nasal mupirocin in the 30 days following discharge to soap without antiseptic properties (placebo) and placebo nasal ointment. This trial seeks to enhance the care of the 675,000 patients annually who undergo colon and small bowel surgery by finding simple and efficacious interventions to reduce SSI.

ICD-10 classifications

Infection following a procedure, not elsewhere classifiedBacterial infection of unspecified siteOther bacterial infections of unspecified siteInfection of obstetric surgical woundOther specified local infections of skin and subcutaneous tissue

Data source

Registry: ClinicalTrials.gov
Trial ID: NCT05586776
Type: Non-Device Trial

About this record

Access comprehensive clinical trial information for NCT05586776 through Pure Global AI's free database. This Phase 4 trial is sponsored by University of California, Irvine and is currently Not yet recruiting. The study focuses on Surgical Site Infection. Target enrollment is 2700 participants.

This page provides complete trial specifications, intervention details, outcomes, and location information. Pure Global AI offers free access to ClinicalTrials.gov data, helping medical device and pharmaceutical companies navigate clinical research efficiently.