Does Severity of Airflow Obstruction Correlate to Static Lung Volumes - Trial NCT05616780
Access comprehensive clinical trial information for NCT05616780 through Pure Global AI's free database. This phase not specified trial is sponsored by Virginia Hawkins and is currently Not yet recruiting. The study focuses on Pulmonary Disease, Chronic Obstructive. Target enrollment is 150 participants.
This page provides complete trial specifications, intervention details, outcomes, and location information. Pure Global AI offers free access to ClinicalTrials.gov data, helping medical device and pharmaceutical companies navigate clinical research efficiently.
Study Focus
Sponsor & Location
Virginia Hawkins
Manchester Metropolitan University
Timeline & Enrollment
N/A
Nov 15, 2022
Mar 31, 2023
Primary Outcome
Measurement of lung volumes by two routine techniques in patients referred for pulmonary function testing.
Summary
Obstructive lung disease is defined by limitations in expiratory airflow, caused by excess
 mucus, loss of muscle tone, and structural changes. Over time airflow reduction can lead to
 gas trapping in the lungs (hyperinflation). Hyperinflation is linked to diminished exercise
 tolerance, shortness of breath, and a poor quality of life. Early treatment options include
 inhalers and pulmonary rehabilitation; however, surgical intervention and oxygen therapy may
 be required in the later stages. More prompt, accurate diagnosis will help to improve patient
 outcomes and optimise their treatment pathways.
 
 Two methodologies used to determine lung volumes and hyperinflation, are nitrogen washout and
 body plethysmography. The accuracy of each in defining lung volumes in patients with
 obstructive lung disease is debated in literature. Plethysmography requires the patient to
 sit in an enclosed box and perform a panting manoeuvre and uses measured changes in volume
 and pressure to derive lung volumes. Plethysmography has been suggested to overestimate lung
 volumes in patients with obstructive lung disease. On the other hand, nitrogen washout relies
 on 'washing out' all the nitrogen from the lungs to calculate lung volumes. Gas trapping and
 poor airflow circulation that occurs in patients with airflow obstruction may lead to
 underestimated lung volumes.
 
 This study will aim to investigate if there is a significant difference between lung volumes
 obtained by both nitrogen washout and body plethysmography in patients with obstructive lung
 disease. Subjects with mild, moderate, severe, and very severe obstruction, including those
 with no obstruction for comparison will be included, with approximately 10 from each group.
 They will be asked if they consent to undergo an extra test during their routine hospital
 appointment, which will add ~15 minutes to their visit.
ICD-10 Classifications
Data Source
ClinicalTrials.gov
NCT05616780
Non-Device Trial