Micro and Macro Circulation in Sepsis - Trial NCT05694455
Access comprehensive clinical trial information for NCT05694455 through Pure Global AI's free database. This phase not specified trial is sponsored by Denver Health and Hospital Authority and is currently Recruiting. The study focuses on Sepsis,Septic Shock. Target enrollment is 150 participants.
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Study Focus
Sponsor & Location
Denver Health and Hospital Authority
Timeline & Enrollment
N/A
Jul 01, 2022
Jun 30, 2023
Primary Outcome
Need for Renal Replacement Therapy
Summary
Purpose: To assess the prognostic role of Handheld Vital Microscopy (HVM) and evaluate levels
 of endothelial glycocalyx (eGC) breakdown in patients demonstrating Hemodynamic Incoherence
 (HI), to elucidate a mechanistic link between the eGC and HI in order to inform prognostic
 enrichment of future resuscitation trials. We will serially evaluate MiH and the perfused
 boundary region (PBR, an visual proxy for eGC thickness) using HVM, and a validated
 circulating biomarker of eGC integrity.
ICD-10 Classifications
Data Source
ClinicalTrials.gov
NCT05694455
Non-Device Trial