Comparing Impacts of Donor Human Milk to Formula Supplementation on the Gut Microbiome of Full-term Infants

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The goal of this pilot randomized controlled trial (RCT) is to examine donor human milk (DHM)
 as a clinical intervention targeted at achieving beneficial microbiome signatures in
 full-term infants who are exposed to intrapartum antibiotic prophylaxis (IAP) therapy during
 labour. Secondarily, this study aims to compare the infant health outcomes of sleep and
 growth between groups to assess if these outcomes are mediated by infant feeding type or
 potential differences in microbial signatures. Finally, this study will compare maternal
 outcomes of depression, anger, breastfeeding self-efficacy and breastfeeding rates between
 groups.
 
 The hypothesis of this study is: that replacing formula with DHM supplementation will
 minimize gut microbiome dysbiosis and foster homeostasis following supplementation. In
 addition, it is hypothesized that improved homeostasis will promote improved sleep and growth
 outcomes in participant infants. Finally, mothers whose infants receive DHM will have lower
 depression and anger scores and high breastfeeding self-efficacy and exclusive breastfeeding
 rates compared to mothers whose infants receive formula.