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NCT05918757

Efficacy and Safety of Administration of High Levels of Protein to Critically Ill Patients.

Exploratory Study to Evaluate the Efficacy and Safety of Nutritional Administration of 1.5 g of Protein/kg/Day Versus 1.0 g of Protein/kg/Day in the Catabolic Phase of Critically Ill Patients Receiving Mechanical Ventilation.
Spanish Society of Critical Care Medicine and Coronary Units·ClinicalTrials.gov·otherRecruiting
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Study focus
Disease/Condition
Intensive Care Unit Acquired Weakness
Drug/Device/Intervention
Protein dose 1.5 g/kg/day
Study type
Interventional
Intervention type
other
Sponsor & location
Primary sponsor
Spanish Society of Critical Care Medicine and Coronary Units
Location
Badalona,L'Hospitalet De Llobregat,Castelló de la Plana,Badajoz,Barbastro,Fuenlabrada,Parla,Manacor,Cartagena,El Palmar,Pozo Aledo,Girona,Granada,Huesca,Madrid,Madrid,Murcia,Málaga, Spain
Timeline & enrollment
Phase
N/A
Start date
Jan 01, 2022
End date
Dec 01, 2023
Enrollment
200 participants
Primary outcome

Change of intensive care unit acquired weakness (ICUAW).

Summary

Critically ill patients are known to develop serious nutritional deterioration during the
 course of their disease. They develop, from the beginning, a multifactorial protein
 malnutrition that relates to a poor clinical course and the development of weakness. Due to
 the increased protein catabolism in this type of patient, there is a rapid degradation of
 muscle mass and loss of functional proteins, and therefore nutritional support is mandatory.
 Indeed, achieving a high protein intake may promote a better evolution of the critically ill
 patient, i.e., maintenance of muscle protein, less deterioration of muscle strength, lower
 Intensive care unit-acquired weakness (ICUAW), lower mortality, decrease in the number of
 infections, decrease in days on mechanical ventilation, and days of hospital stay and in ICU.
 
 The goal of this clinical trial is to compare the appearance and degree of ICUAW in
 critically ill patients receiving invasive mechanical ventilation treated with two different
 doses of protein (1.5 g/kg/day vs.1.0 g/kg/day).

ICD-10 classifications
Acute respiratory failureAcute renal failure with medullary necrosisAcute renal failureAcute renal failure, unspecifiedOther acute renal failure
Data source
Registry
ClinicalTrials.gov
Trial ID
NCT05918757
Type
Non-Device Trial
About this record

Access comprehensive clinical trial information for NCT05918757 through Pure Global AI's free database. This phase not specified trial is sponsored by Spanish Society of Critical Care Medicine and Coronary Units and is currently Recruiting. The study focuses on Intensive Care Unit Acquired Weakness. Target enrollment is 200 participants.

This page provides complete trial specifications, intervention details, outcomes, and location information. Pure Global AI offers free access to ClinicalTrials.gov data, helping medical device and pharmaceutical companies navigate clinical research efficiently.