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NCT05927129

Research on the Biological Mechanism of the Efficacy of Psychotherapy for Depression Based on the fNIRS

Research on the Biological Mechanism of the Efficacy of Psychotherapy for Depression Based on the Near-Infrared Functional Imaging System (fNIRS)
First Affiliated Hospital of Zhejiang University·ClinicalTrials.gov·drugRecruiting
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Study focus
Disease/Condition
Depressive Disorder
Drug/Device/Intervention
Antidepressant
Study type
Interventional
Intervention type
drug
Sponsor & location
Primary sponsor
First Affiliated Hospital of Zhejiang University
Location
Zhejiang, China
Timeline & enrollment
Phase
N/A
Start date
Jan 01, 2022
End date
Dec 31, 2024
Enrollment
90 participants
Primary outcome

Changes in fNIRS (functional Near-Infrared Spectroscopy) after treatment.,Change in remission rate of Hamilton Depression Scale (24-items) (HAM-D24) score after treatment.

Summary

In this project, the investigators will implement medication therapy, psychotherapy, and a
 combination of medication therapy with psychotherapy, specifically utilizing IPT, in patients
 with depression. Simultaneously, the investigators will conduct comprehensive fNIRS
 assessments on all patients to evaluate changes in their brain function and determine the
 level of effectiveness of psychotherapy. The investigators will also employ standardized
 psychological assessments to evaluate patients, allowing for a comparison of the
 effectiveness of fNIRS assessments and providing clarity on the efficacy of psychotherapy in
 patients with depression, as the investigatorsll as the differential efficacy of different
 treatment approaches, and establishing the biological markers of psychotherapy. Additionally,
 the investigators will collect blood samples, cranial magnetic resonance images, and
 electroencephalograms from patients before and after treatment, which will contribute to
 further exploration of treatment mechanisms in the future.

ICD-10 classifications
Depressive conduct disorderRecurrent depressive disorder, unspecifiedRecurrent depressive disorderOther recurrent depressive disordersRecurrent depressive disorder, currently in remission
Data source
Registry
ClinicalTrials.gov
Trial ID
NCT05927129
Type
Non-Device Trial
About this record

Access comprehensive clinical trial information for NCT05927129 through Pure Global AI's free database. This phase not specified trial is sponsored by First Affiliated Hospital of Zhejiang University and is currently Recruiting. The study focuses on Depressive Disorder. Target enrollment is 90 participants.

This page provides complete trial specifications, intervention details, outcomes, and location information. Pure Global AI offers free access to ClinicalTrials.gov data, helping medical device and pharmaceutical companies navigate clinical research efficiently.