Role of Curcumin in Paclitaxel Induced PN - Trial NCT05966441
Access comprehensive clinical trial information for NCT05966441 through Pure Global AI's free database. This Phase 2 trial is sponsored by Ain Shams University and is currently Not yet recruiting. The study focuses on Chemotherapy-induced Peripheral Neuropathy. Target enrollment is 80 participants.
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Study Focus
Sponsor & Location
Ain Shams University
Timeline & Enrollment
Phase 2
Aug 30, 2023
Mar 10, 2024
Primary Outcome
Evaluate the effect of Curcumin on the incidence and severity of paclitaxel-induced peripheral neuropathy (PIPN) in breast cancer patients.,Evaluate the effect of Curcumin on the damage of nerve fibers induced by paclitaxel.
Summary
Paclitaxel induced peripheral neuropathy is the most common and serious side effect
 associated with Paclitaxel treatment in breast cancer patients receiving Paclitaxel.
 
 The efficacy of antioxidant molecules as neuroprotective strategies to preventing the
 development of peripheral neuropathy has been investigated in preclinical and clinical
 studies. Vitamin E and Glutathione have been explored as adjuvant therapies to preventing
 taxane-induced peripheral neuropathy. Other tested neuroprotective treatments with limited
 success include amifostine, glutamine and acetyl l-carnitine. Curcumin's antioxidant capacity
 is similar to other potent antioxidants, such as trolox (a vitamin E analog). Curcumin
 inhibits lipid peroxidation in different tissues, regulates intracellular levels of
 antioxidant enzymes (e.g., catalase, glutathione peroxidase and superoxide dismutase) and is
 an effective intracellular reactive oxygen species (ROS) scavenger.
 
 The investigators are going to investigate the neuroprotective effect of Curcumin against
 Paclitaxel induced peripheral neuropathy.
ICD-10 Classifications
Data Source
ClinicalTrials.gov
NCT05966441
Non-Device Trial