DDX17 Orchestrate Septic Vascular Endothelial Pyroptosis by Controlling Gasdermin D Pore Formation

28-day mortality

Objective: To investigate the correlation between plasma levels of DDX17 and GSDMD with
 vascular endothelial dysfunction and prognosis of in sepsis patients.
 
 Design: A single center, prospective, observational research. Participants: Patients with
 sepsis who are hospitalized to Southeast University Affiliated Zhongda Hospital and meet the
 diagnostic criteria for sepsis 3.0.
 
 Inclusion criteria:1. There is a potential or clear infection; 2. Sequential organ failure
 score (SOFA score) increases by more than or equal to 2 points compared to the baseline
 value; 3. Sign informed consent form.
 
 Exclusion criteria: Age18 years old or80 years old, pregnant women, tumor patients,
 including diseases that may be complicated with vascular endothelial damage: hypertension,
 acute and chronic hepatitis (hepatitis caused by virus), liver cirrhosis, PT prolongation
 after liver transplantation, acute myocardial infarction, chronic tubular nephritis, chronic
 renal insufficiency/maintenance hemodialysis, renal transplantation, interstitial pneumonia,
 acute pancreatitis, active phase of systemic lupus erythematosus Ulcerative colitis, Crohn's
 disease, HELLP syndrome.
 
 Primary outcome: 28-day mortality. Secondary outcome: Plasma levels of DDX17 and GSDMD, and
 their correlation with vascular endothelial injury, severity, and prognosis in sepsis
 patients.