Effectiveness of Adjunctive Therapy of Emdogain®FL in Non-surgical Periodontal Treatment

Changes in Pocket Probing Depth (PPD)

The goal of this clinical trial is to assess the safety and effectiveness of adjunctive
 Emdogain® therapy in non-surgical periodontal treatment for patients with stage 3 and 4
 periodontitis.
 
 The main questions it aims to answer are:
 
 - Will adjunctive treatment with Emdogain® result in a greater reduction in Bleeding on
 Probing and probing pocket depth compared to non-surgical periodontal treatment alone? •
 Will adjunctive treatment with Emdogain® lead to a greater mean Radiographic attachment
 level (rAL) gain per quadrant compared to non-surgical periodontal treatment alone?
 
 - Will adjunctive treatment with Emdogain® result in a lower proportion of treated teeth
 requiring surgery (PPD ≥6mm) at 12 months after treatment?
 
 Participants in the study will undergo the following tasks:
 
 - Screening and randomization
 
 - Receival of non-surgical periodontal treatment in all quadrants and in two quadrants
 adjunctive Emdogain®
 
 - 6-month follow-up assessment
 
 - 12-month follow-up assessment
 
 Clinical and radiological assesment will be performed in two quadrants treated with
 adjunctive Emdogain® therapy and two quadrants treated with non-surgical periodontal
 treatment alone. This comparison will help determine the effects of adjunctive therapy with
 Emdogain®.
 
 The study aims to provide insights into the safety and efficacy of adjunctive Emdogain®
 therapy in non-surgical periodontal treatment, specifically in patients with stage 3 and 4
 periodontitis.