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NCT06092437

Investigating a Tailored Diuretic Algorithm in Acute Heart Failure Patients

TAILOR-AHF: Randomized Trial Investigating a Tailored Diuretic Algorithm in Acute Heart Failure Patients
Zuyderland Medisch Centrum·ClinicalTrials.gov·otherRecruiting
View on ClinicalTrials.gov →
Study focus
Disease/Condition
Heart Failure Acute
Drug/Device/Intervention
Urine sodium guided diuretic algorithm
Study type
Interventional
Intervention type
other
Sponsor & location
Primary sponsor
Zuyderland Medisch Centrum
Location
Heerlen, Netherlands
Timeline & enrollment
Phase
N/A
Start date
Feb 27, 2023
End date
Feb 27, 2026
Enrollment
466 participants
Primary outcome

Hierarchical composite of all-cause mortality, heart failure events and delta quality of life at 90 days follow-up.

Summary

Acutely decompensated heart failure (ADHF) is highly prevalent and has a high (financial)
 burden on the health care system. Treatment often consists of the administration of IV
 decongestive agents. Adequate dosing is difficult due to varying diuretic resistance and
 inadequate parameters to evaluate the response. Urine sodium is a promising biomarker to
 evaluate the diuretic response. It is hypothesized that a tailored, urine sodium guided
 diuretic algorithm will result in faster and more complete decongestion and therefore lead to
 better survival (in terms of mortality and heart failure events) while being non-inferior in
 terms of safety (mainly regression of kidney function).

ICD-10 classifications
Heart failureHeart failure, unspecifiedCongestive heart failureInjury of heartInjury of heart, unspecified
Data source
Registry
ClinicalTrials.gov
Trial ID
NCT06092437
Type
Non-Device Trial
About this record

Access comprehensive clinical trial information for NCT06092437 through Pure Global AI's free database. This phase not specified trial is sponsored by Zuyderland Medisch Centrum and is currently Recruiting. The study focuses on Heart Failure Acute. Target enrollment is 466 participants.

This page provides complete trial specifications, intervention details, outcomes, and location information. Pure Global AI offers free access to ClinicalTrials.gov data, helping medical device and pharmaceutical companies navigate clinical research efficiently.