Effect of Green Coffee Extract Combined With Alpha-Lipoic Acid on Blood Glucose Homeostasis in Healthy Adults

Glucose incremental area under the curve

Green coffee extract (GCE) supplementation has been shown to induce favourable health
 benefits on glucose metabolism and weight management. Previous literature suggests that the
 benefits of GCE are due to the high bioavailability of chlorogenic acid (CGA) which is known
 for its antioxidant and anti-inflammatory properties but is destroyed during the bean
 roasting process used to make coffee in Western societies. Whilst some studies examining
 chronic and high dose GCE supplementation (4-12 weeks) report beneficial effects on glucose
 metabolism and reductions in body mass following supplementation, comparably less is known
 about the effect of acute (single dose) GCE supplementation. Another natural compound,
 alpha-lipoic acid (ALA) has antioxidant properties and may also benefit glucose metabolism.
 The purpose of the current study is to determine the impact of acute supplementation of GCE
 with ALA on postprandial blood glucose concentration following consumption of a carbohydrate
 drink in healthy adults. A secondary objective is to evaluate the effect of GCE+ALA on blood
 insulin concentrations, insulin sensitivity, glucose oxidation, and perceptions of appetite.