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NCT06154642

Perioperative Hemodynamic and Microcirculatory Physiological Study During TAVI

Physiological Study of Hemodynamic and Microcirculatory Evolution Before/After Transcatheter Aortic Valve Replacement (TAVI)
University Hospital, Geneva·ClinicalTrials.gov·diagnostic testNot yet recruiting
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Study focus
Disease/Condition
Aortic Valve Stenosis
Drug/Device/Intervention
Determination of arterial compliance using blood pressure waveform analysis
Study type
Observational
Intervention type
diagnostic test
Sponsor & location
Primary sponsor
University Hospital, Geneva
Timeline & enrollment
Phase
N/A
Start date
Jan 02, 2024
End date
Jul 31, 2024
Enrollment
20 participants
Primary outcome

Modification in arterial stiffness in large- and small-caliber arteries,Modification in plasma Vascular Endothelium Growth Factor levels,Modification in skin surface temperature gradient,Modification in reactive hyperemia

Summary

The Physiological Study of Haemodynamic and Microcirculatory Evolution before/after
 Transcatheter Aortic Valve Replacement (TAVI) aims to investigate the physiological changes
 induced by the implantation of a prosthetic aortic valve on blood vessels in patients with
 severe aortic stenosis. The hypothesis of the study is that adaptive microcirculatory
 phenomena occur during TAVI implantation. The results of preoperative assessment of
 microcirculatory functional reserve differ according to whether or not organ dysfunction
 occurs after TAVI. There is a progressive adaptation of the microcirculation to the new
 cardiovascular load conditions after TAVI. Early features of this adaptation are associated
 with the occurrence of short- and medium-term complications.

ICD-10 classifications
Aortic (valve) stenosisAortic (valve) stenosis with insufficiencyCongenital stenosis of aortic valveStenosis of aortaRheumatic aortic stenosis
Data source
Registry
ClinicalTrials.gov
Trial ID
NCT06154642
Type
Non-Device Trial
About this record

Access comprehensive clinical trial information for NCT06154642 through Pure Global AI's free database. This phase not specified trial is sponsored by University Hospital, Geneva and is currently Not yet recruiting. The study focuses on Aortic Valve Stenosis. Target enrollment is 20 participants.

This page provides complete trial specifications, intervention details, outcomes, and location information. Pure Global AI offers free access to ClinicalTrials.gov data, helping medical device and pharmaceutical companies navigate clinical research efficiently.