Oral Health Status of Cystic Fibrosis Patients. An Online Survey in Collaboration With the Vaincre la Mucoviscidose Patient Association. - Trial NCT06356246

Timeline & Enrollment

Primary Outcome

Periodontal Risk Screening Score PESS

Summary

Cystic Fibrosis (CF) is a rare hereditary disease with autosomal recessive transmission,
 affecting 1 in 4700 births in France. Numerous studies have explored the links between oral
 health and CF, predominantly focusing on a children population. These studies reveal
 hyposalivation, a risk of dental erosion, an increased prevalence of enamel structural
 defects, but a reduced prevalence of dental caries in CF children, potentially explained by
 better oral hygiene. Periodontal disease does not appear to be increased in this population,
 while the oral quality of life of CF patients has been insufficiently studied.
 
 Today, emerging challenges arise due to the increased life expectancy of CF patients,
 attributed to the rise of modulators such as Kaftrio®, resulting in an adult-majority
 population in France. The study of periodontal diseases, associated with oral dysbiosis,
 becomes relevant as they represent bacterial reservoirs that could impact respiratory
 complications in CF patients.
 
 To deepen understanding of the links between oral health and CF, as well as to improve oral
 health of these patients, it is crucial to update the specific oral profile of this
 population. A cross-sectional survey using a questionnaire is proposed to include a large
 number of CF patients in France, aiming for real-life data. This questionnaire is constructed
 around internationally recognized tools for comparative analysis with normative data.
 Collaboration with the Patients Association Vaincre la Mucoviscidose (VLM) facilitates
 questionnaire creation, dissemination, and interpretation of results.

ICD-10 Classifications