Effect of Herring Oil Concentrate on LDL Cholesterol Concentration in Adults - Trial NCT06364163
Access comprehensive clinical trial information for NCT06364163 through Pure Global AI's free database. This phase not specified trial is sponsored by University of Bergen and is currently Not yet recruiting. The study focuses on High Cholesterol. Target enrollment is 80 participants.
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Study Focus
Sponsor & Location
University of Bergen
Timeline & Enrollment
N/A
Aug 12, 2024
Dec 31, 2027
Primary Outcome
Serum concentration of LDL-cholesterol
Summary
High cholesterol concentration is a major risk factor for cardiovascular disease (CVD), and
 consumption of fish has been associated with a lower CVD risk in several studies. The
 beneficial health effects of consuming fish have traditionally been ascribed to the
 long-chain PUFA (LC-PUFA) EPA (C20:5n-3) and DHA (C22:6n-3), although consumption of fish
 oils or concentrates with high EPA and DHA contents does not affect the cholesterol
 concentration in humans and lowers the cholesterol concentration in rats and mice only when
 given in very high doses. Fish oils contain a plethora of fatty acids besides EPA and DHA,
 and in recent years, increased focus has been on the long-chain MUFA (LC-MUFA) cetoleic acid
 (C22:1n-11). Cetoleic acid is found in high amounts in oils from certain fish species such as
 herring, which has relatively low contents of both EPA and DHA. The investigators have
 recently summarised and meta-analysed the available literature that investigates the effects
 of diets containing fish oils or fish oil concentrates that have a high content of cetoleic
 acid but low or no content of EPA and DHA on cholesterol concentration in rodents, showing
 that cetoleic acid-rich fish oils and concentrates prevent high cholesterol concentration.
ICD-10 Classifications
Data Source
ClinicalTrials.gov
NCT06364163
Non-Device Trial