Effects of Liposomal Encapsulation on Vitamin C Absorption and Metabolism - Trial NCT06372171
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Study Focus
Sponsor & Location
National Yang Ming University
Timeline & Enrollment
N/A
Apr 01, 2024
Dec 01, 2024
Primary Outcome
General examination,Hematology Test
Summary
Vitamin C is an important antioxidant in the human body and plays many important roles. It is
 currently known that vitamin C has the functions of treating scurvy, assisting in collagen
 synthesis, whitening, and increasing immunity. Smokers, patients with cardiovascular disease,
 and patients with diabetes may have higher requirements for vitamins due to higher oxidative
 stress in the body. Liposome coating is a technology commonly used in food processing and
 medicine to protect active substances, increase absorption or slow release. Currently,
 vitamin C is commonly available on the market as an additive nutritional supplement in the
 form of powder packets, tablets, etc. The disadvantages are that vitamin C is relatively
 unstable, easily destroyed by gastric acid, and maintains blood concentration for a short
 time. Taking liposome microbial C has been Found to have the potential to increase
 bioavailability in the human body, it is expected that vitamin C coated with lecithin is
 relatively stable and can be stabilized in the small intestine without being damaged by
 gastric acid, while reducing the risk of gastrointestinal discomfort caused by the acidity of
 vitamin C. According to the revised seventh edition of the Reference Intake of Dietary
 Nutrients for Chinese People, the upper daily intake of vitamin C (tolerable upper intake
 levels, UL) for people aged 19 to 70 is 2,000 mg. According to literature, the absorption
 rate of vitamin C when consuming 30-180 mg per day is about 70-90%; when the daily intake
 exceeds 1000 mg, the absorption rate will drop to less than 50%. The dose of vitamin C used
 in this study is more than 1500 mg. The purpose is to explore whether the sustained-release
 characteristics of liposome coating technology can improve the absorption rate and achieve
 better bioavailability when consuming high-dose vitamin C powder. It is expected that through
 the egg The liposome vitamin C powder made of phospholipids increases its maintenance time in
 the blood, thereby increasing the supplementary effect of vitamin C powder and serving as
 another supplement option for vitamin C.
ICD-10 Classifications
Data Source
ClinicalTrials.gov
NCT06372171
Non-Device Trial