Prediction of Outcomes in Patients With Chronic Heart Failure Based on Tissue Raman Spectroscopy - Trial NCT06393595

Timeline & Enrollment

Primary Outcome

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Summary

Chronic heart failure (CHF) is a syndrome complicating heart disease, the prevalence of which
 has reached epidemic levels. According to global statistics the most common causes of CHF are
 coronary heart disease (CHD): 26.5%, arterial hypertension (AH):26.2% . The category of
 patients with CHD complicated by CHF prevails in clinical practice, requiring an optimized
 approach to determining prognosis in order to improve the effectiveness of therapy. In the
 literature, this issue has been studied with the use of general clinical, biochemical,
 instrumental criteria. Nevertheless, the problem of optimized prognosis in patients with CHF
 remains. Its solution may lie in the study of metabolic parameters of biological media -
 skin, blood serum by Raman spectroscopy.
 
 Skin is an accessible tissue for studying the effects of a wide range of age-dependent
 noncommunicable diseases, including cardiovascular disease, type 2 diabetes mellitus, and
 chronic kidney disease. We were one of the first to use skin RS as a method of determining
 renal dysfunction, a necessary component of chronic kidney disease. However, the
 applicability of RS/SERS in the diagnosis and prognosis of specific diseases, as well as in
 the collection of statistical data for this analytical approach, remains an open question .
 Despite the fact that the method is classified as analytical, it can be used to identify not
 so much specific chemical molecules as their specific loci, which provide vibrations that
 change the wavelengths of the scattered spectrum. The resulting spectrum can be presented as
 a metabolic portrait of the disease, with the most informative loci, the combination of
 which is associated with a negative prognosis.
 
 The innovative analytical methods of optical spectroscopy proposed in this project provide
 new level information about hundreds of molecules and their active centers that have
 prospects as biomarkers. This study aims to determine the clinical relevance of skin and
 serum RS in patients with CHF, realized on state-of-the-art instrumentation in a
 comprehensive patient study setting. The research proposed in this project will contribute to
 the development of high-tech production of new optical devices for rapid diagnosis and
 prognosis of a wide range of diseases.

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