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NCT06398873

Effect of Dupilumab on Nasal Epithelial Barrier Function in Patients With CRSwNP

Effect of Dupilumab on Nasal Epithelial Barrier Function in Patients With Chronic Rhinosinusitis With Nasal Polyps (CRSwNP) - an Exploratory Pilot Study
Medical University of Vienna·ClinicalTrials.gov·drugNot yet recruiting
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Study focus
Disease/Condition
Chronic Rhinosinusitis With Nasal Polyps,Chronic Rhinosinusitis Without Nasal Polyps
Drug/Device/Intervention
Dupilumab 300 MG/2 ML Subcutaneous Solution [DUPIXENT]
Study type
Observational
Intervention type
drug
Sponsor & location
Primary sponsor
Medical University of Vienna
Location
Vienna, Austria
Timeline & enrollment
Phase
N/A
Start date
May 15, 2024
End date
Sep 01, 2027
Enrollment
80 participants
Primary outcome

Barrier function in CRSsNP and CRSwNP,Barrier function in CRSwNP with Dupilumab

Summary

The investigators aim to investigate two major so far unresolved topics in CRSwNP research:
 (1) Thorough functional and molecular characterisation of barrier function in patients
 suffering from CRSsNP and CRSwNP and (2) effect of dupilumab treatment on barrier function in
 polyp patients. This will be achieved in patient-derived samples by employing measurement of
 barrier function in primary cell cultures in combination with a mass cytometry based imaging
 approach, transcriptomic analysis as well as cytokine and microbiome data of individual
 patients.

ICD-10 classifications
Nasal polypNasal polyp, unspecifiedPolyp of nasal cavityOther polyp of sinusOther chronic sinusitis
Data source
Registry
ClinicalTrials.gov
Trial ID
NCT06398873
Type
Non-Device Trial
About this record

Access comprehensive clinical trial information for NCT06398873 through Pure Global AI's free database. This phase not specified trial is sponsored by Medical University of Vienna and is currently Not yet recruiting. The study focuses on Chronic Rhinosinusitis With Nasal Polyps,Chronic Rhinosinusitis Without Nasal Polyps. Target enrollment is 80 participants.

This page provides complete trial specifications, intervention details, outcomes, and location information. Pure Global AI offers free access to ClinicalTrials.gov data, helping medical device and pharmaceutical companies navigate clinical research efficiently.