Concentration of Receptors With Affinity for Cannabidiol and Cannabinol and the Effect on Chronic Orofacial Pain of Muscle Origin

Relationship between the concentration of receptors with affinity for Cannabidol and Cannabinol and the risk of occurrence and severity of chronic orofacial pain of muscle origin,Assessment of the occurrence of chronic orofacial pain of muscular origin assessed using the Diagnostic Criteria for Temporomandibular Disorders (DC/TMD) protocol.

The main aim of the presented project will be to examine the concentration of selected
 receptors (CB1, CB2, TRPV-1) showing affinity for binding to cannabidol (CBD) and cannabinol
 (CBN) in blood samples collected from people with chronic pain in the masticatory muscles and
 from people without this pain. Moreover, study participants will be examined by a qualified
 doctor, according to the validated and standardized international DC/TMD protocol (Diagnostic
 Criteria for Temporomandibular Disorders) and the criteria included in ICOP-1 (International
 Classification of Orofacial Pain, 1st edition). The nature and duration of pain,
 psychoemotional state and central sensitization (the phenomenon of increased reactivity of
 the nervous system to stimuli) will be determined using validated questionnaires. The
 obtained results will be subjected to statistical analysis in order to check the
 relationships between the examined parameters.