Concentration of Receptors With Affinity for Cannabidiol and Cannabinol and the Effect on Chronic Orofacial Pain of Muscle Origin - Trial NCT06405646
Access comprehensive clinical trial information for NCT06405646 through Pure Global AI's free database. This phase not specified trial is sponsored by Wroclaw Medical University and is currently Enrolling by invitation. The study focuses on Myalgia,Muscle Pain,Orofacial Pain,Headache, Tension,Headaches Muscular. Target enrollment is 102 participants.
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Study Focus
Blood CB1, CB2, TRPV-1 concentration measurement
Observational
diagnostic test
Sponsor & Location
Wroclaw Medical University
Timeline & Enrollment
N/A
Jun 01, 2024
Dec 01, 2024
Primary Outcome
Relationship between the concentration of receptors with affinity for Cannabidol and Cannabinol and the risk of occurrence and severity of chronic orofacial pain of muscle origin,Assessment of the occurrence of chronic orofacial pain of muscular origin assessed using the Diagnostic Criteria for Temporomandibular Disorders (DC/TMD) protocol.
Summary
The main aim of the presented project will be to examine the concentration of selected
 receptors (CB1, CB2, TRPV-1) showing affinity for binding to cannabidol (CBD) and cannabinol
 (CBN) in blood samples collected from people with chronic pain in the masticatory muscles and
 from people without this pain. Moreover, study participants will be examined by a qualified
 doctor, according to the validated and standardized international DC/TMD protocol (Diagnostic
 Criteria for Temporomandibular Disorders) and the criteria included in ICOP-1 (International
 Classification of Orofacial Pain, 1st edition). The nature and duration of pain,
 psychoemotional state and central sensitization (the phenomenon of increased reactivity of
 the nervous system to stimuli) will be determined using validated questionnaires. The
 obtained results will be subjected to statistical analysis in order to check the
 relationships between the examined parameters.
ICD-10 Classifications
Data Source
ClinicalTrials.gov
NCT06405646
Non-Device Trial