Exercise Therapy on Mitochondrial Functions of Lymphocyte in Hemodialysis

Mitochondrial function of lymphocyte

To improve aerobic capacity, muscular function and health-related quality of life in patients
 with end-stage renal disease (ESRD), regular exercise is recommended. Supervised
 intradialytic exercise with moderate intensity is an available approach to maintain patients'
 safety and compliance, and enhance physiological adaptations effectively. The exercise
 training effects of mitochondrial functions of lymphocyte in ESRD patients, like respiratory
 capacity, bioenergetic status and thrombosis/immunological regulation remained unclear.
 
 Method: ESRD patients (anticipated n=180) would conduct supervised exercise training therapy
 for 3 days a week for 6 months in the hospital and 3 months at home. Cardiopulmonary exercise
 therapy would be performed before and after the intervention. A high resolution respirometer
 and a flow cytometer are used to determine the oxygen consumption rate/mitochondrial
 respiration in mitochondria and subtypes of lymphocyte, respectively.