Pre-emptive oral pregablin in postoperative pain after orthopedic lower limb surgeries under spinal anesthesia - Trial PACTR201711002742202
Access comprehensive clinical trial information for PACTR201711002742202 through Pure Global AI's free database. This Not Applicable trial is sponsored by tanta university hospital and is currently Not yet recruiting. The study focuses on Surgery; Other.
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Study Focus
drug
Sponsor & Location
tanta university hospital
Tanta university hospital
Timeline & Enrollment
Not Applicable
Jan 01, 1900
Jan 01, 1900
Summary
Postoperative analgesia is an integral part of successful surgical outcome. Epidural analgesia with catheter technique remains the most effective analgesic technique after abdominal surgery. However, it has limitation in patients who are either on anticoagulants and have cardiac morbidity due to significant hemodynamic changes which may be detrimental to such patientsNeuraxial anesthesia is the most commonly used technique for providing perioperative analgesia in abdominal and lower limb surgeries. The use of local anesthetic adjuvant are associated with better outcomes and decreased the risk of hemodynamic changes, however, the risk of certain complication as inadequate analgesia, postoperative nauseas and vomiting, and pruritis remainsPregabalin is an r-aminobutyric acid analog that binds to the a2-d subunit of presynaptic voltage-gated calcium channels. It reduces the depolarization-induced calcium influx at nerve terminals, with a consequent reduction in the release of several excitatory neurotransmitters, including glutamate
ICD-10 Classifications
Data Source
Pan Africa Clinical Trials Registry
PACTR201711002742202
Non-Device Trial