PACTR202007664590852

Intrathecal Versus Intravenous Tramadol in prevention of Post-spinal anaesthesia Shivering

Suez Canal University Hospitals·Not Applicable·Pan Africa Clinical Trials RegistryCompleted
Study focus
Disease/Condition
Anaesthesia
Sponsor & location
Primary sponsor
Suez Canal University Hospitals
Funder
self funded
Location
Egypt
Timeline & enrollment
Phase
Not Applicable
Start date
Aug 09, 2020
End date
Jan 06, 2021
Summary

Spinal anesthesia (SA) is a very common technique used by anesthesiologist (1). It involves the injection of a local anaethetic into the subarachnoid space to anaesthetize the lower part of the body. Shivering is a common complication following SA. The incidence varies from 40% to 70%.[1] It is a spontaneous, involuntary and oscillatory fasciculations, or tremor-like hyperactivity of the skeletal muscles.[2] This makes it distressing for both the patient and the surgeon. It increases metabolic rate, oxygen consumption, CO2 production, heart rate, and blood pressure.[1,2] These increase the cardiac workload leading to wound pain, delay wound healing, and prolong hospital stay. It also interferes with the perioperative vital monitoring and increases intraocular and intracranial pressures.[1] All these sequelae coupled with the high incidence of postopearative shivering makes its prophylaxis imperative.Prophylaxis with intravenous (IV) tramadol produces a dose-dependent reduction in the incidence of postanesthesia shivering.[3] Tramadol is a commonly used intrathecal (IT) adjuvant. It prolongs the duration of sensory and motor block, and improves postoperative analgesia.Few studies assess antishivering efficacy of IT tramadol .[2] So the present study aims to compare the antishivering effect of both routes of tramadol (IT and IV) in patients undergoing lower limb orthopedic surgeries under SA. references:1. De Witte J, et al. Perioperative shivering:Physiology and pharmacology.Anesthesiology.2002;96:467–84 2. Prasad RB, et al. Effectiveness of addition of intrathecal tramadol with hyperbaric bupivacaine in prevention of shivering in parturients undergoing caesarean section under spinal anaesthesia: A randomized placebo-controlled study. Karnataka Anaesth J. 2015;1:123–7. 3. Mohta M, et al. Tramadol for prevention of postanaesthetic shivering: A randomised double-blind comparison with pethidine. Anaesthesia. 2009;64:141–6.

ICD-10 classifications
Anaesthetic, unspecifiedOther and unspecified general anaestheticsOther complications of anaesthesiaLocal anaestheticsAnaesthesia of skin
Data source
Registry
Pan Africa Clinical Trials Registry
Trial ID
PACTR202007664590852
Type
Non-Device Trial
About this record

Access comprehensive clinical trial information for PACTR202007664590852 through Pure Global AI's free database. This Not Applicable trial is sponsored by Suez Canal University Hospitals and is currently Completed. The study focuses on Anaesthesia.

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