Therapeutic effect of early cardiac rehabilitation combined with melatonin supplementation after acute myocardial infarction treated by primary percutaneous coronary intervention. - Trial PACTR202208834230748
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Study Focus
Sponsor & Location
Department of cardiology University Hospital Hedi Chaker
Department of Cardiology Hedi Chaker University Hospital
Timeline & Enrollment
Not Applicable
Jan 01, 1900
Jan 01, 1900
Summary
Myocardial infarction (MI), happens when one or more areas of the heart muscle don't get enough oxygen which is most often caused by plaque rupture with thrombus formation in an epicardial coronary artery, resulting in an acute reduction of blood supply to a portion of the myocardium. Patients with acute myocardial infarction (AMI) following primary percutaneous coronary intervention have a reduced exercise capacity with a low value of VO2 peak which is related to a reduced cardiac output ,a mitochondrial dysfunction and an endothelial dysfunction generated by the increase of reactive oxygen species (ROS) due to the sudden reintroduction of oxygen . In addition, the excessive production of ROS after reperfusion can aggravate the cardiac dysfunction caused by the myocardial cell death. After MI, there is an imbalance in cardiac autonomic modulation characterized by an increase of the sympathetic system and a decrease of the parasympathetic system. Furthermore, sleep disturbances observed in people suffering from coronary artery diseases are due to the circadian misalignment by the decrease in nocturnal concentrations of melatonin, a neurohormone that regulates the biological clock. Moreover, this hormone has a cardioprotective effect due to its to its antioxidative, antiapoptotic, and anti-inflammatory actions. Early cardiac rehabilitation started within one month after discharge is an effective therapy and plays a key role in the management of patients with MI which may alleviate impairment in aerobic capacity, cardiovascular dysfunction, quality of sleep, autonomic cardiac dysfunction and oxidative stress.This is the first prospective study that investigate the chronic effect (12 weeks ) of early cardiorespiratory rehabilitation combined with melatonin supplementation in patients post AMI
ICD-10 Classifications
Data Source
Pan Africa Clinical Trials Registry
PACTR202208834230748
Non-Device Trial