Off-pump versus on-pump coronary artery bypass grafting in patients with chronic obstructive pulmonary disease - Trial PACTR202302897543202

Timeline & Enrollment

Summary

Chronic lung disease is a well-known risk factor for operative mortality from cardiac surgery, and, hence, it is included in EuroSCORE II. Chronic obstructive pulmonary disease (COPD) is inflammation of the airway, alveoli and small blood vessels, which leads to remodelling at the level of small airways.Patients with COPD are at a higher risk for postoperative complications, such as respiratory failure, pneumonia, atrial fibrillation (AF) and acute respiratory distress syndrome (ARDS). Despite the widely used CPB to perform CABG, off-pump CABG has become increasingly an area of interest because of the avoidance of the use of CPB and its associated systemic inflammatory response. Also, patients now have multiple morbid conditions, like diabetes, obesity, COPD and complex coronary artery disease (CCAD). A major benefit of CABG without CPB is that there is no aortic manipulation for aortic cannulation and no aortic cross-clamping. The aim of the present trial is to compare the outcome of coronary artery bypass grafting with and without cardiopulmonary bypass in patients of chronic obstructive pulmonary disease.

ICD-10 Classifications