Evaluation of Transperineal Biopsy Under Local Anesthesia

Change in infection adverse events, as measured on Transrectal Ultrasound Guided prostate Biopsy Questionnaire (TRUS-BxQ)

Approximately one million transrectal prostate biopsies are performed annually in the U.S.,
 and the risk of post- biopsy infection is increasing due to greater antibiotic resistance of
 rectal flora. Preliminary data demonstrates that a transperineal MRI-targeted biopsy approach
 under local anesthesia compared to the standard practice transrectal MRI-targeted prostate
 biopsy has a much lower risk of infection, comparable pain/discomfort and may improve
 detection of prostate cancer.
 
 This randomized controlled trial will be the first prospective study to evaluate in-office
 transperineal MRI targeted prostate biopsy.
 
 The investigators hypothesize that a transperineal MRI-targeted biopsy approach under local
 anesthesia compared to the standard practice transrectal MRI-targeted prostate biopsy has a
 much lower risk of infection, comparable pain/discomfort and may improve detection of
 prostate cancer.