Role of FFR in ACS Patients: Pressure ACS Registry

Rate of Major adverse cardiac events

Currently, fractional flow reserve (FFR) is regarded as a gold-standard invasive method to
 define lesion-specific ischemia and FFR-guided PCI has been proven to reduce unnecessary
 revascularization and to enhance patient's clinical outcomes. Therefore, current guidelines
 recommend FFR measurement for intermediate coronary stenosis when there is no definite
 evidence of lesion-specific ischemia. However, previous evidences which well demonstrated the
 benefit of FFR-guided strategy were mostly generated from patients with stable coronary
 artery disease.4 FFR may be overestimated and the hemodynamic relevance of a coronary
 stenosis underestimated in patients with acute coronary syndrome (ACS).Its role in ACS
 patients still needs to be defined although several studies have recently published
 addressing the value of FFR-guided PCI in ACS. In fact, recent evidence suggests that culprit
 lesions of patients presenting with a non-ST-segment elevation myocardial infarction that
 were deferred based on a negative FFR have a relatively high event rate, calling into
 question the use of FFR in that patient population.