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NCT05915117

Effects of Polyphenols of Pomegranate Fruit Peel Extract on Inflammation and Oxidative Stress in Metabolic Syndrome

Randomized, Double-blind, Placebo-controlled Study of Efficacy Polyphenols of Pomegranate Fruit Peel Extract on Inflammatory Parameters and Oxidative Stress in Overweight and Obese Subjects With Metabolic Syndrome
University of Banja Luka·ClinicalTrials.gov·dietary supplementNot yet recruiting
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Study focus
Disease/Condition
Metabolic Syndrome
Drug/Device/Intervention
Polyphenols of pomegranate fruit peel extract (PoPex)
Study type
Interventional
Intervention type
dietary supplement
Sponsor & location
Primary sponsor
University of Banja Luka
Location
Banja Luka, Bosnia and Herzegovina
Timeline & enrollment
Phase
N/A
Start date
Apr 01, 2023
End date
Aug 20, 2024
Enrollment
60 participants
Primary outcome

Change in oxidative stress biomarkers levels: lipid peroxidation index, nitric oxide metabolites, hydrogen peroxide (H2O2), superoxide anion radical (O2-), and glutation (GSH), catalasis(CAT) and superoxid dismutasis(SOD).,Change in proinflammatori parametars:interleukin-6 (IL-6), tumor necrosis factor-α (TNF- α), high sensitive CRP (hsCRP), leptin, resistin ,vaspin, chemerin ,lipokalin -2 and katepsin,Change in antiinflammatori parametars:interleukin -5 (IL-5) ,interleukin-10(IL-10), interleukin-12 (IL-12) ,adiponectin and omentin

Summary

The purpose of this study is to evaluate the effects of polyphenols of pomegranate fruit peel
 extract compared to placebo on oxidative stress and inflammation in overweight and obese
 subjects with metabolic syndrome.

ICD-10 classifications
Metabolic disordersMetabolic disorder, unspecifiedOther metabolic disordersOther specified metabolic disordersNutritional and metabolic disorders in diseases classified elsewhere
Data source
Registry
ClinicalTrials.gov
Trial ID
NCT05915117
Type
Non-Device Trial
About this record

Access comprehensive clinical trial information for NCT05915117 through Pure Global AI's free database. This phase not specified trial is sponsored by University of Banja Luka and is currently Not yet recruiting. The study focuses on Metabolic Syndrome. Target enrollment is 60 participants.

This page provides complete trial specifications, intervention details, outcomes, and location information. Pure Global AI offers free access to ClinicalTrials.gov data, helping medical device and pharmaceutical companies navigate clinical research efficiently.