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NCT06011876Recruiting

BioFLO for Respiratory Recovery in SCI

Genetic Biomarkers of Intermittent Hypoxia-Induced Respiratory Motor Plasticity in Chronic SCI
University of FloridaClinicalTrials.govother
Verified
Study focus
Disease/Condition
Spinal Cord Injuries
Drug/Device/Intervention
Acute Intermittent Hypoxia (AIH)
Study type
Interventional
Intervention type
other
Sponsor & location
Primary sponsor
University of Florida
Location
Jacksonville, United States of America
Timeline & enrollment
Phase
N/A
Start date
Dec 01, 2023
End date
Sep 01, 2027
Enrollment
62 participants
Primary outcome

Change in motor evoked potential,Change in maximal inspiratory pressure,Change in maximal expiratory pressure

Summary

Acute intermittent hypoxia (AIH) involves brief (1 min), repeated episodes (~15) of breathing
 low oxygen air to stimulate spinal neuroplasticity. Animal and human studies show that AIH
 improves motor function after spinal cord injury, particularly with slightly increased carbon
 dioxide (hypercapnic AIH; AIHH) and task-specific training. Using a double blind cross-over
 design, the study will test whether AIHH improves breathing more than AIH and whether
 specific genetic variations are related to individuals' intervention responses.

ICD-10 classifications
Sequelae of injury of spinal cordOther and unspecified injuries of thoracic spinal cordOther and unspecified injuries of cervical spinal cordOther injury of lumbar spinal cordInjury of spinal cord, level unspecified
Data source
Registry
ClinicalTrials.gov
Trial ID
NCT06011876
Type
Non-Device Trial
About this record

Access comprehensive clinical trial information for NCT06011876 through Pure Global AI's free database. This phase not specified trial is sponsored by University of Florida and is currently Recruiting. The study focuses on Spinal Cord Injuries. Target enrollment is 62 participants.

This page provides complete trial specifications, intervention details, outcomes, and location information. Pure Global AI offers free access to ClinicalTrials.gov data, helping medical device and pharmaceutical companies navigate clinical research efficiently.