The Effects of Chicken Extract on Mental Energy in Healthy Adults and the Underlying Mechanisms

Reaction time and sustained attention (composite) assessed by Cogstate Brief Battery (CBB),Reaction time assessed by Deary-Liewald reaction time task,Sustained attention assessed by psychomotor vigilance test,Sustained attention assessed by trail making test,Fatigue assessed by Profile of Mood States (POMS),Fatigue assessed by visual analogue scale (VAS),Vigor assessed by Profile of Mood States (POMS),Vigor assessed by visual analogue scale (VAS),Motivation assessed by visual analogue scale (VAS),Cerebral blood flow using arterial spin labelling magnetic resonance imaging (MRI),Cerebral oxygenation using functional MRI blood oxygenation level dependent (BOLD) imaging,Whole body metabolic rate using indirect calorimetry,Plasma global metabolome (metabolic profile) using liquid chromatography mass spectrometry (LCMS),Salivary cortisol level,Plasma carnosine,Plasma anserine,Plasma L-histidine,Plasma methylhistidine,Plasma beta-alanine

This exploratory trial investigates the effect of a chicken extract supplement on mental
 energy and its potential underlying mechanisms of action among healthy adults using a
 randomized, double-blind, placebo-controlled clinical trial design. Mental energy is a
 multi-dimensional construct comprising transient feelings about fatigue, vigor and motivation
 and cognitive performance in terms of sustained attention and reaction time.
 
 A sub-study investigates the immediate biochemical changes after taking chicken extract.