Do Ketone Drinks Improve Immune, Metabolic and Cognitive Health in Older Adults

Change in 24hr average glucose area under the curve (AUC)

The goal of this randomised, double-blinded, placebo-controlled trial is to investigate the
 immune, metabolic and cognitive effects of four weeks of daily ketone supplementation in
 adults aged 60 to 80 with stable health. The main objectives are to assess the effects of the
 intervention versus placebo on markers of metabolic health, inflammation, immune function,
 adipose tissue, and cognitive performance.
 
 Participants will undergo two weeks of baseline monitoring followed by a four-week
 supplementation period in which they will drink a ketone monoester drink or taste-matched
 placebo three times a day. During these periods, participants will record their diet and
 supplement intake and their physical activity and blood glucose will be monitored using
 wearable devices. At the beginning and end of the supplementation period, participants will
 undergo testing in the university physiology laboratories, involving blood, expired air and
 adipose tissue samples, as well as cognitive tests, physical tests and questionnaires.