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NCT06091800

Interleukin 20 and Periodontal Tisuue Destruction

Determination of Levels of IL-20, TNF-α, IL1β/IL-10, RANKL/OPG and MMP8 in Serum and Gingival Crevicular Fluid (GCF) in Peridontally Healthy and Periodontitis Individuals
Recep Tayyip Erdogan University·ClinicalTrials.gov·otherCompleted
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Study focus
Disease/Condition
Periodontitis
Drug/Device/Intervention
biochemical analysis
Study type
Observational
Intervention type
other
Sponsor & location
Primary sponsor
Recep Tayyip Erdogan University
Location
Rize, Turkey
Timeline & enrollment
Phase
N/A
Start date
Jun 06, 2022
End date
Jun 06, 2023
Enrollment
60 participants
Primary outcome

concentration of biochemical findings in gingival crevicular fluid (GCF),concentration of biochemical findings in serum

Summary

Periodontitis is an inflammatory disease that causes destruction of periodontal tissues.
 IL-20, on the other hand, is known as a potent angiogenic, chemotactic, and pro-inflammatory
 cytokine associated with various chronic inflammatory disorders. IL-20 has a significant role
 in the regulation of osteoclastogenesis and osteoblastogenesis. The aim of this study was to
 evaluate the effect of IL-20 on periodontal destruction.
 
 In the study, a total of 60 participants were included, 30 of whom were systemically and
 periodontally healthy (control group) and 30 of whom were systemically healthy and had
 periodontitis (periodontitis group). GCF and serum samples were collected from the
 participants for biochemical analysis. ELISA method was used to determine IL-20, TNF-α,
 IL1β/IL-10, RANKL/OPG and MMP8 levels

ICD-10 classifications
Chronic periodontitisPeriodontosisAcute periodontitisChronic apical periodontitisPeriodontal disease, unspecified
Data source
Registry
ClinicalTrials.gov
Trial ID
NCT06091800
Type
Non-Device Trial
About this record

Access comprehensive clinical trial information for NCT06091800 through Pure Global AI's free database. This phase not specified trial is sponsored by Recep Tayyip Erdogan University and is currently Completed. The study focuses on Periodontitis. Target enrollment is 60 participants.

This page provides complete trial specifications, intervention details, outcomes, and location information. Pure Global AI offers free access to ClinicalTrials.gov data, helping medical device and pharmaceutical companies navigate clinical research efficiently.