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Allogeneic Gammadelta T Cells Combined With Interferon-α1b or PD-1 Monoclonal Antibody in Stage III-IV Amenable to Surgical Resection Melanoma - Trial NCT06212388

Access comprehensive clinical trial information for NCT06212388 through Pure Global AI's free database. This Phase 1 trial is sponsored by Xijing Hospital and is currently Not yet recruiting. The study focuses on Melanoma. Target enrollment is 10 participants.

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NCT06212388
Phase 1
Not yet recruiting
biological
Trial Details
ClinicalTrials.govNCT06212388
View on ClinicalTrials.gov
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Allogeneic Gammadelta T Cells Combined With Interferon-α1b or PD-1 Monoclonal Antibody in Stage III-IV Amenable to Surgical Resection Melanoma
Efficacy and Safety of Allogeneic γδ T Cells (γδ T Cells) Combined With Interferon-alpha1b (IFN-α1b) or PD-1 Monoclonal Antibody in Neoadjuvant Treatment of Stage III-IV Resectable Melanoma

Study Focus

Melanoma

Ex-vivo expanded allogeneic γδ T cells

Interventional

biological

Sponsor & Location

Xijing Hospital

Timeline & Enrollment

Phase 1

Jan 24, 2024

Oct 30, 2028

10 participants

Primary Outcome

Rate of Pathological Complete Response (pCR),Rate of Major Pathological Response (mPR),Rate of Partial Pathological Response (pPR),Overall Response Rate(ORR)

Summary

The purpose of this study is to evaluate the efficacy and safety of allogeneic γδ T cells
 combined with recombinant human interferon-α1b (IFN-α1b) or PD-1 monoclonal antibody in
 neoadjuvant treatment of patients with Stage III-IV resectable melanoma.

ICD-10 Classifications

Malignant melanoma of skin
Melanoma in situ, unspecified
Melanoma in situ
Melanoma and other malignant neoplasms of skin
Malignant neoplasm: Malignant melanoma of skin, unspecified

Data Source

ClinicalTrials.gov

NCT06212388

Non-Device Trial