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NCT06235320Not yet recruiting

Paracetamol Effect on Prostaglandins and Blood Pressure

Paracetamol Impact Study: Prostaglandin Synthesis and Blood Pressure Effects (PIS-PaB)
Charite University, Berlin, GermanyClinicalTrials.govother
Verified
Study focus
Disease/Condition
Pain
Drug/Device/Intervention
routine clinical treatment of pain with paracetamol or ibuprofen
Study type
Observational
Intervention type
other
Sponsor & location
Primary sponsor
Charite University, Berlin, Germany
Timeline & enrollment
Phase
N/A
Start date
Mar 01, 2024
End date
Mar 01, 2026
Enrollment
72 participants
Primary outcome

Prostanoid levels

Summary

This research program aims to investigate the influence of paracetamol on blood pressure and
 the cyclooxygenase (COX) - prostaglandine (PG) pathway in patients with pain. Through an
 observational pilot study, we will use advanced LC/ESI-MS/MS methodology to analyze the
 COX-OG pathway in plasma and urine. The study will assess the effects of paracetamol compared
 to ibuprofen, considering different types of pain. The primary focus is to understand the
 changes in blood pressure and the COX-PG pathway upon initiation or discontinuation of
 paracetamol, with safety analysis as a secondary consideration.

ICD-10 classifications
Pain, unspecifiedPain, not elsewhere classifiedPain in limbAcute painOther chronic pain
Data source
Registry
ClinicalTrials.gov
Trial ID
NCT06235320
Type
Non-Device Trial
About this record

Access comprehensive clinical trial information for NCT06235320 through Pure Global AI's free database. This phase not specified trial is sponsored by Charite University, Berlin, Germany and is currently Not yet recruiting. The study focuses on Pain. Target enrollment is 72 participants.

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