Correlation Between Depression Scores and Serum NF-ĸB/NLRP3 Axis, Biotinidase, and HMGB After Treatment With Isotretinoin in Patients With Acne Vulgaris

change in biotinidase level

Acne is a chronic inflammatory disease of the pilosebaceous unit resulting from
 androgen-induced increased sebum production, altered keratinization, inflammation, and
 bacterial colonization of hair follicles on the face, neck, chest, and back by, Cutibacterium
 acnes. Although all age groups can be affected, it is primarily a disease of adolescence.
 Treatment selection is based on disease severity, patient preference, and tolerability.
 Isotretinoin is drug of chioce used for moderate and severe acne. Isotretinoin results in a
 significant reduction in sebum production, influences comedogenesis, lowers surface and
 ductal c. acnes and has anti-inflammatory properties. Biotin deficiency may be caused by
 insufficient dietary uptake of biotin, drug- vitamin interactions and increased biotin
 catabolism during pregnancy and in smokers. Biotin deficiency can also be precipitated by
 decreased activities of biotinidase, which plays a central role in the intestinal absorption
 of biotin