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NCT06244914Recruiting

Combined taVNS and tDCS in Subacute Stroke Patients

Combining Closed-loop Transcutaneous Auricular Vagus Nerve Stimulation and Focal Transcranial Direct Current Stimulation as an Adjuvant Treatment for Acute and Subacute Strokes
National Cheng-Kung University HospitalClinicalTrials.govdeviceDevice trial
Study focus
Disease/Condition
Ischemic Stroke
Drug/Device/Intervention
tDCS stimulation
Study type
Interventional
Intervention type
device
Sponsor & location
Primary sponsor
National Cheng-Kung University Hospital
Location
Tainan city, Taiwan
Timeline & enrollment
Phase
N/A
Start date
Feb 15, 2024
End date
Apr 30, 2027
Enrollment
80 participants
Primary outcome

Disability Severity Assessment Using the Modified Rankin Scale (mRS),Motor Function Assessment Using Fugl-Meyer Assessment (FMA) for Upper Extremity (UE) and Lower Extremity (LE),Upper Limb Motor Function Evaluation Using the Wolf Motor Function Test (WMFT),Mobility and Balance Assessment Using the Time Up and Go Test (TUG)

Summary

Ischemic stroke, the most prevalent neurological disorder, is treated with medication and
 thrombectomy but with limited success, especially in chronic stages where traditional
 rehabilitation is the primary option. Stroke often leads to post-stroke autonomic imbalance,
 deteriorating functional outcomes and increasing recurrence risk. Emerging
 non-pharmacological treatments like Transcutaneous Auricular Vagus Nerve Stimulation (VNS)
 and Focused Transcranial Direct Current Stimulation (tDCS) offer new possibilities. VNS
 targets post-stroke tissue injury and promotes healing and neurogenesis, while tDCS aims to
 enhance motor learning by rebalancing brain activity. Both therapies seek to improve outcomes
 in both acute and chronic stroke stages.

ICD-10 classifications
Stroke, not specified as haemorrhage or infarctionSequelae of stroke, not specified as haemorrhage or infarctionCerebral infarctionCerebral infarction, unspecifiedOther cerebral infarction
Data source
Registry
ClinicalTrials.gov
Trial ID
NCT06244914
Type
Device Trial
About this record

Access comprehensive clinical trial information for NCT06244914 through Pure Global AI's free database. This phase not specified trial is sponsored by National Cheng-Kung University Hospital and is currently Recruiting. The study focuses on Ischemic Stroke. Target enrollment is 80 participants.

This page provides complete trial specifications, intervention details, outcomes, and location information. Pure Global AI offers free access to ClinicalTrials.gov data, helping medical device and pharmaceutical companies navigate clinical research efficiently.