Value of PET/MR Enterography in the Assessment of Crohn's Disease Using a Collagen-binding Radiotracer.

Detection Rate of Fibrotic Strictures with [68Ga]CBP8-PET PET/MRE.

In this study twenty-five (25) subjects with Crohn's disease scheduled for possible surgical
 intervention will be recruited for this study and a PET/MR scan using the collagen-binding
 radiotracer will be performed. The study aims to establish the performance figures of PET/MR
 using [68Ga]CBP8-PET for preoperative detection and differentiation of strictures with a
 fibrotic component in patients with Crohn's disease by using surgical and histologic findings
 (when available) as the standard for comparison. Furthermore, the investigators will
 determine the performance figures with which strictures are identified and characterized by
 PET/MR using [68Ga]CBP8-PET compared to each modality in isolation (PET alone or MR alone).
 Blood and tissue markers for fibrostenosis will be explored (either predictive or as
 biomarkers for fibrotic burden), using histologic and molecular testing by using surgical and
 histologic findings (when available) as the standard for comparison. Lastly the investigators
 want to determine the performance figures with which strictures are identified and
 characterized by PET/MR using [68Ga]CBP8-PET compared to each modality in isolation (PET
 alone or MR alone).