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NCT06255067

Efficacy of Noisome as A Carrier of Locally Delivered Minocycline Hydrochloride Gel

Efficacy of Noisome as A Carrier of Locally Delivered Minocycline Hydrochloride Gel in Stage II or Stage III Periodontitis: A Randomized Controlled Clinical Trial With Biochemical Analysis
Ain Shams University·Phase 2/3·ClinicalTrials.gov·drugNot yet recruiting
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Study focus
Disease/Condition
Periodontitis
Drug/Device/Intervention
Minocycline hydrochloride with noisome carrier
Study type
Interventional
Intervention type
drug
Sponsor & location
Primary sponsor
Ain Shams University
Location
Cairo,Cairo, Egypt
Timeline & enrollment
Phase
Phase 2/3
Start date
Feb 25, 2024
End date
Jun 30, 2024
Enrollment
30 participants
Primary outcome

To measure clinical assessment Plaque Index (PI) in both groups (mincycline hydrochloride with noisome as carrier & minocycline hydrochloride only),To measure clinical assessment Gingival Index (GI) in both groups (mincycline hydrochloride with noisome as carrier & minocycline hydrochloride only),To measure Clinical attachment level (CAL) in both groups (mincycline hydrochloride with noisome as carrier & minocycline hydrochloride only),To measure Periodontal Pocket Depth (PPD) in both groups (mincycline hydrochloride with noisome as carrier & minocycline hydrochloride only)

Summary

The goal of this clinical trial is to compare the efficacy of Noisome as carrier of
 minocycline hydrochloride gel to minocycline hydrochloride in Stage II or Stage III
 Periodontitis . The main questions it aims to answer are:
 
 - Is the Noisome carrier of minocycline hydrochloride has an effect in comparing to
 minocycline hydrochloride in Stage II or Stage III Periodontitis?
 
 - what is the release profile of of minocycline hydrochloride noisome gel and minocycline
 hydrochloride gel? Participants will be asked to maintain oral hygiene after application
 of treatment Researchers will compare the effect of noisome as a carrier of locally
 delivered minocycline hydrochloride gel to minocycline hydrochloride gel in stage II or
 stage III periodontitis patients as an adjunct to non-surgical periodontal treatment] to
 see if Plaque Index (PI) , Gingival index,Clinical attachment level (CAL) &Periodontal
 Pocket Depth decreased or not.

ICD-10 classifications
Chronic periodontitisPeriodontosisAcute periodontitisChronic apical periodontitisPeriodontal disease, unspecified
Data source
Registry
ClinicalTrials.gov
Trial ID
NCT06255067
Type
Non-Device Trial
About this record

Access comprehensive clinical trial information for NCT06255067 through Pure Global AI's free database. This Phase 2/3 trial is sponsored by Ain Shams University and is currently Not yet recruiting. The study focuses on Periodontitis. Target enrollment is 30 participants.

This page provides complete trial specifications, intervention details, outcomes, and location information. Pure Global AI offers free access to ClinicalTrials.gov data, helping medical device and pharmaceutical companies navigate clinical research efficiently.