Evolution of the Clinical, Immuno-virological and Aging Trajectory of Patients Living With HIV

measure of the frequency of circulating leukocyte cells,measure the number of hematopoietic stem cells in peripheral blood and their ability to develop a myeloid or lymphoid lineage in culture

Main objective is:
 
 - To characterize the evolution of the immuno-virological profile of circulating blood
 cells and immune aging in patients who had participated to TEMPO-1 in 2007-2008
 
 - To evaluate the role of immune aging and inflammatory profile in the occurrence of
 comorbidities in HIV-infected individuals over a 15-year period
 
 The alterations that affect the innate and adaptive immune cell compartments in HIV-infected
 patients are reminiscent of the process of immune aging, characteristic of old age. These
 alterations, the presumed cause of which is the chronic systemic immune activation
 established in patients, contribute to the depletion of lymphoid resources which probably
 leads to the decline of immune competence with the progression of HIV disease.
 
 The comparison between HIV-1-infected patients and uninfected older adults goes beyond the
 mere appearance of immunosenescence and extends to the deterioration of a number of
 physiological functions linked to inflammation and to systemic aging.
 
 By inducing persistent and lasting immune activation, HIV-1 infection is now considered a
 model of accelerated immunosenescence and systemic aging. During this process, the immune
 system quickly becomes exhausted, because the source of its exhaustion (i.e. HIV) cannot be
 eliminated.
 
 To determine which factors may contribute to immunosenescence in HIV-1 infection, we propose
 an extensive immune and virological evaluation in patients who participated in a
 cross-sectional assessment of immune functions and TEMPO-1 viral reservoirs after 15 years of
 evolution in order to determine their immune and viral trajectories, to compare these
 trajectories with the major clinical events and the comorbidities occurring in them.