Applying Directly Observed Therapy to Hydroxyurea to Realize Effectiveness

Retention Rate,Sustained Engagement,Electronic Adherence

This study is for caregivers of young children with sickle cell disease and adolescents with
 sickle cell disease who are currently prescribed hydroxyurea and are receiving care at one of
 the study sites. The study will assess retention and engagement during a pilot randomized
 control trial comparing video directly observed therapy (VDOT) to attention control. We also
 hope to understand more about patient and family preferences longer-term adherence monitoring
 and intervention.
 
 Participants will use an electronic adherence monitor (provided by the study team) to measure
 how often they are taking their hydroxyurea. Participants will also be asked to complete
 questionnaires throughout the study period to provide information about their expectations
 for, experience with, and satisfaction with the study materials.