NCT06273137

Positive Affect Treatment for Adolescents With Early Life Adversity

Name: Clinical Trial NCT06273137
Creator: University of California, Irvine
Keywords: Depression, Positive affect treatment, behavioral, clinical trial, United States of America

Mitigating Depression Among Adversity Exposed Adolescents Using Positive Affect Therapy

University of California, Irvine·ClinicalTrials.gov·behavioralRecruiting

View on ClinicalTrials.gov →

Study focus

Disease/Condition: Depression
Drug/Device/Intervention: Positive affect treatment
Study type: Interventional
Intervention type: behavioral

Sponsor & location

Primary sponsor: University of California, Irvine
Location: Irvine, United States of America

Timeline & enrollment

Phase: N/A
Start date: Feb 03, 2024
End date: Oct 16, 2026
Enrollment: 22 participants

Primary outcome

Positive affect

Summary

Youth exposed to early life adversity (ELA) are known to be at greater risk for depression and suicidality and account for almost half of the youth suffering from psychiatric diseases today. Youth exposed to ELA consistently report symptoms of anhedonia as well as dysregulated positive affect. The present project will test the efficacy of PAT in a sample of ELA-exposed adolescents in order to determine whether PAT increases positive affect, and subsequently symptoms of depression. For this pilot, the investigators will recruit 22 adolescents exposed to two or more childhood adversities (ACEs) who do not currently have major depressive disorder, and randomize them (1:1) to either participate in PAT or a waitlist control condition. At study enrollment, then 4-, 8, and 12-months thereafter the investigators will measure positive affect and depressive symptoms (including anhedonia). The results of this study will be used to inform whether PAT has the potential to prevent major depressive episodes among adversity-exposed youth.

ICD-10 classifications

Depressive episodeOther depressive episodesRecurrent depressive disorderRecurrent depressive disorder, unspecifiedPost-schizophrenic depression

Data source

Registry: ClinicalTrials.gov
Trial ID: NCT06273137
Type: Non-Device Trial

About this record

Access comprehensive clinical trial information for NCT06273137 through Pure Global AI's free database. This phase not specified trial is sponsored by University of California, Irvine and is currently Recruiting. The study focuses on Depression. Target enrollment is 22 participants.

This page provides complete trial specifications, intervention details, outcomes, and location information. Pure Global AI offers free access to ClinicalTrials.gov data, helping medical device and pharmaceutical companies navigate clinical research efficiently.